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We consider the problem of resource provisioning for real-time cyber-physical applications in an open system environment where there does not exist a global resource scheduler that has complete knowledge of the real-time performance requirements of each individual application that shares the resources with the other applications. Regularity-based Resource Partition (RRP) model is an effective strategy to hierarchically partition and assign various resource slices among such applications. However, previous work on RRP model only discusses uniform resource environment, where resources are implicitly assumed to be synchronized and clocked at the same frequency. The challenge is that a task utilizing multiple resources may experience unexpected delays in non-uniform environments, where resources are clocked at different frequencies. This paper extends the RRP model to non-uniform multi-resource open system environments to tackle this problem. It first introduces a novel composite resource partition abstraction and then proposes algorithms to construct and reconfigure the composite resource partitions. Specifically, theAcyclic Regular Composite Resource Partition Scheduling (ARCRP-S)algorithm constructs regular composite resource partitions and theAcyclic Regular Composite Resource Partition Dynamic Reconfiguration (ARCRP-DR)algorithm reconfigures the composite resource partitions in the run time upon requests of partition configuration changes. Our experimental results show that compared with state-of-the-art methods, ARCRP-S can prevent unexpected resource supply shortfall and improve the schedulability up to 50%. On the other hand, ARCRP-DR can guarantee the resource supply during the reconfiguration with moderate computational overhead. 

Abstract Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle that serves as a signaling hub for the cell. Using proximity labeling and quantitative proteomics, we identify Numb as a ciliary protein that positively regulates Hh signaling. Numb localizes to the ciliary pocket and acts as an endocytic adaptor to incorporate Ptch1 into clathrin-coated vesicles, thereby promoting Ptch1 exit from the cilium, a key step in Hh signaling activation. Numb loss impedes Sonic hedgehog (Shh)-induced Ptch1 exit from the cilium, resulting in reduced Hh signaling. Numb loss in spinal neural progenitors reduces Shh-induced differentiation into cell fates reliant on high Hh activity. Genetic ablation of Numb in the developing cerebellum impairs the proliferation of granule cell precursors, a Hh-dependent process, resulting in reduced cerebellar size. This study highlights Numb as a regulator of ciliary Ptch1 levels during Hh signal activation and demonstrates the key role of ciliary pocket-mediated endocytosis in cell signaling. 

We consider the problem of resource provisioning for real-time cyber-physical applications in an open system environment where there does not exist a global resource scheduler that has complete knowledge of the real-time performance requirements of each individual application that shares the resources with the other applications. Regularity-based Resource Partition (RRP) model is an effective strategy to hierarchically partition and assign various resource slices among the applications. However, RRP model does not consider changes in resource requests from the applications at run time. To allow for the run time adaptation to change resource requirements, we consider in this paper the issues in online resource partition reconfiguration, including semantics issues that arise in configuration transitions that may cause application failures. Based on the reconfiguration semantics, we study the online resource reconfigurability problem under the RRP model where the availability factors of resource partitions may be reconfigured during run time. We formalize the Dynamic Partition Reconfiguration (DPR) problem and provide a solution to this problem. Extensive experiments have been conducted to evaluate the performance of the proposed approach in different scenarios. We also present a case study using the autonomous F1/10 model car; the controller of the F1/10 car requires resource adaptation to satisfy the computing needs of its PID controller and vision system under different operating conditions. Our implementation demonstrates the effectiveness and benefit of online resource partition reconfiguration using the DPR approach in a real system.